Bruker says timsTOF mass spectrometry maps 179,000 human plasma proteoforms in draft atlas
BRKR•Bruker highlighted a preprint describing a draft human plasma atlas that mapped 179,049 proteoforms across 5,077 protein groups using timsTOF systems. A high-confidence set covered 44,083 proteoforms.
1. Draft plasma atlas
Researchers reported mapping 5,077 plasma protein groups across 179,049 proteoforms, with a high-confidence set covering 44,083 proteoforms. The work used intact-protein fractionation with diaPASEF and aimed for higher-throughput discovery without nanoparticle-based enrichment.
2. Research applications
The results point to broader protein diversity than canonical protein lists, which can drive mismatches across proteomics measurement platforms. Bruker also highlighted its timsOmni platform for deeper top-down proteoform sequencing in biomarker and drug-target research workflows.
