In Brazil, political developments remained in the spotlight.
Brazil's opposition is set to take to the streets on Monday as right-wing presidential hopeful Senator Flavio Bolsonaro seeks to capitalize on a crisis engulfing the country's Supreme Court to bolster his campaign against leftist President Luiz Inacio Lula da Silva ahead of next month's election.
Recent polls showed Lula's lead over Bolsonaro narrowing, with investors widely considering the challenger to be a more market-friendly candidate amid a deteriorating fiscal situation under the current government.
Chile, the world's largest copper producer, exported $4.63 billion worth of the metal in August, down 3.2% from the same month a year earlier, the country's central bank said on Monday.
MSCI's index tracking Chilean stocks .MICL00000PUS was slightly lower while the Chilean peso CLP= strengthened 0.1%.
Chile's central bank is expected on Tuesday to leave interest rates unchanged.
Mexico's equities benchmark .MXX and the Mexican peso MXN= both fell 0.2%. Mexico is the region's second-largest economy.