Exelixis jumps as Q1 EPS beats, $750M new buyback adds support

EXELEXEL

Exelixis shares are higher after reporting Q1 2026 results with total revenue of $610.8 million and GAAP diluted EPS of $0.79. The company also authorized an additional stock repurchase program of up to $750 million through the end of 2027 and reiterated 2026 revenue guidance of $2.525–$2.625 billion.

1. What’s moving the stock

Exelixis (EXEL) is trading higher Wednesday after the company reported first-quarter 2026 financial results after the close on May 5, 2026, showing stronger profitability and announcing incremental shareholder returns via a new buyback authorization. Investors are focusing on the combination of higher earnings and the expanded repurchase capacity, which can reduce share count and lift per-share metrics.

2. The numbers investors are reacting to

For the quarter ended March 31, 2026, Exelixis reported total revenue of $610.8 million and GAAP net income of $210.5 million, translating to GAAP diluted EPS of $0.79. Net product revenue was $555.0 million, reflecting higher sales volume, while collaboration revenue was $55.8 million; the company also maintained its fiscal 2026 total revenue outlook of $2.525 billion to $2.625 billion.

3. Buyback and pipeline updates add to the bid

Exelixis said its board authorized an additional stock repurchase program of up to $750 million by December 31, 2027, on top of completing its current $750 million repurchase program. The company also highlighted ongoing progress in its zanzalintinib program, including an accepted NDA under review with a target action date of December 3, 2026, keeping attention on upcoming clinical and regulatory milestones later this year.