Erasca General Counsel Sells $670,812 of Shares, ERAS-0015 Shows Partial Responses at 8 mg
General counsel Garner Ebun sold 120,000 shares on Jan. 7 for $670,812, cutting his stake by 82.7% to 25,076 shares while retaining 360,000 options. Early Phase 1 data show two confirmed and one unconfirmed partial responses for ERAS-0015 at 8 mg QD with no dose-limiting toxicities; topline data due H1 2026.
1. Insider Sale Signals Significant Stake Reduction
On January 7, Erasca’s general counsel and corporate secretary, Garner Ebun, exercised options on 120,000 shares and immediately sold them in the open market for gross proceeds of $670,812, as disclosed in a Form 4 filing. This transaction reduced Ebun’s direct common stock holdings from 145,076 shares to 25,076 shares, representing an 82.7% decline in direct ownership. The exercise price and sale price were both based on a weighted average of $5.59 per share. Following the sale, Ebun retains 360,000 stock options (vested and unvested), preserving potential for further exercises and monetization. Investors should note that this was not a gift or indirect transfer, but an exercise under a Rule 10b5-1 plan established in June 2024, underscoring that the sale was pre-planned rather than discretionary. Over the past year, the stock has rallied 189.8%, suggesting the sale captured significant unrealized gains during a period of notable appreciation.
2. Clinical Progress for RAS-Targeting Franchise and Funding Runway
Erasca reported encouraging early clinical data for its lead asset ERAS-0015 in the AURORAS-1 Phase 1 trial, with two confirmed and one unconfirmed partial responses observed at an 8 mg once-daily dose, and additional unconfirmed responses at higher dose levels. No dose-limiting toxicities were reported, and adverse events were predominantly low grade, while pharmacokinetics demonstrated linear exposure across doses. ERAS-0015 monotherapy data are expected in H1 2026, with expansion and combination cohorts slated for H2 2026 and additional readouts in 2027. For ERAS-4001, the BOREALIS-1 Phase 1 trial is progressing as planned, targeting KRAS-mutant solid tumors, with initial monotherapy data anticipated in H2 2026 and expansion cohorts in 2027. As of November 2025, Erasca held $362 million in cash, projected to fund operations into the second half of 2028, while quarterly net losses narrowed year over year. Key upcoming catalysts include Phase 1 data readouts, balance sheet durability assessments, and validation of early efficacy signals in larger patient cohorts.