The Dow Jones Industrial Average .DJI fell 113.52 points, or 0.21%, to 53,463.88, the S&P 500 .SPX fell 1.58 points, or 0.02%, to 7,675.70 and the Nasdaq Composite .IXIC fell 21.10 points, or 0.08%, to 26,130.20.
MSCI's gauge of stocks across the globe .MIWD00000PUS rose 0.45 points, or 0.04%, to 1,150.06. Earlier, the pan-European STOXX 600 .STOXX index finished close to flat, down 0.01%.
Trading in energy markets was choppy as investors monitored talks between Iran and Oman on the Strait of Hormuz and assessed a smaller-than-expected rise in U.S. crude stocks.
U.S. crude CLc1 settled down 0.16%, or 13 cents, at $82.23 a barrel while Brent LCOc1 settled at $87.84 per barrel, down 0.84%, or 74 cents.
Oil's fluctuations also appeared to affect the bond market. U.S. Treasury yields edged higher after the inflation data while traders also monitored Middle East developments and weighed U.S. government plans to expand debt buybacks.
The yield on benchmark U.S. 10-year notes US10YT=RR rose 0.75 basis points to 4.647%, from 4.639% late on Tuesday while the 30-year bond US30YT=RR yield fell 0.58 basis points to 5.1682%.
The 2-year note US2YT=RR yield, which typically moves in step with interest rate expectations for the Federal Reserve, rose 0.74 basis points to 4.211%.
Odds that rates would stay steady rose to roughly 64% from 60.4% on Tuesday, while bets for a 25 basis point interest rate hike in September dropped to 36% from almost 40% the day before, according to CME Group's FedWatch Tool. However, rates are still expected to rise by year-end.