Novo says CagriSema shows greater weight loss than Lilly rival in diabetes patients

At Novo's capital markets day on Monday, the company detailed a multi-year rollout for its next-generation obesity injectables, targeting a launch of its CagriSema combination early next year.

Novo's U.S.-listed shares were down more than 4% before the bell as analysts questioned the drugmaker's pricing power and dealmaking strategy ahead of looming patent expiries.

In the late-stage study, a 1 mg dose of Novo's drug CagriSema was superior to Lilly's tirzepatide at 5 mg for weight loss, the company said on Monday. Lilly's tirzepatide, the active ingredient in its diabetes drug Mounjaro and obesity drug Zepbound, showed a weight loss of 9.1%.

While the low-dose data is encouraging, the findings were less impactful given tirzepatide has already been proven superior to higher doses of Novo's CagriSema in obesity, said BMO analyst Evan Seigerman.

In patients with diabetes, Novo's drug also showed demonstrated non-inferior blood sugar reduction compared to Lilly's tirzepatide.

In another late-stage study, the drug showed a 21% weight loss at a 1.0 mg dose compared to placebo in adults with obesity.

A decision from the U.S. Food and Drug Administration on the company's application for CagriSema for weight management is expected in the fourth quarter.

Sept. 21 (Reuters) - Novo Nordisk said on Monday its next-generation experimental drug, CagriSema, delivered an estimated average weight loss of 12.4% in a late-stage trial in patients with diabetes, outperforming Eli Lilly's rival drug.

It has been viewed as a successor to Novo's blockbuster weight-loss drug, Wegovy, which faces patent expiries after 2030, and could help the Danish drugmaker claw back ground lost to Lilly in the fast-growing weight-loss market.