The sanctions drive compounds the toll of the war on Iran's economy, where annual inflation hit 66% last month.
Supreme Leader Ayatollah Mojtaba Khamenei, who was injured and has not been seen publicly since the February 28 attack that killed his father, former Supreme Leader Ali Khamenei, called on the government to tackle the economic hardship.
"There is the need to seriously address the chain of economic and livelihood challenges, such as inflation, unemployment, management of prices and the market for goods and services," said a written statement attributed to Khamenei.
Iranian President Masoud Pezeshkian told state media that Iranian exports and imports slumped nearly 35% because of U.S. sanctions and a naval blockade of Iranian ports.
But he said Iran was able to sell about 90 million barrels of oil during the short-lived memorandum of understanding that the U.S. and Iran signed in June, when Washington permitted Iranian oil sales.
With the U.S. focused on its economic pressure campaign, others have sought to revive diplomatic efforts to end the war.
Qatari Prime Minister Sheikh Mohammed bin Abdulrahman Al Thani met with Iranian leaders in Tehran on Thursday. He said he had stressed during the meeting the importance of returning to the pre-war status of open shipping through the Strait of Hormuz.
Iranian Foreign Minister Abbas Araqchi on Friday described the talks with Al Thani as "creative."
Qatar, a U.S. ally and Gulf neighbour to Iran, and Pakistan helped broker the June memorandum of understanding that led to a brief ceasefire before disagreements over the strait caused it to unravel.
U.S. military commanders say American forces have cleared sea mines from the strait that had been laid months ago by Iran's Islamic Revolutionary Guard Corps.
Trump has repeatedly said the strait is open, but the Islamic Revolutionary Guard Corps' navy said in a statement that such claims "are an obvious lie," reiterating that the waterway remained closed to ships without Iranian permission.
Preliminary shipping data released on Friday showed that only seven commodity vessels had transited the Strait of Hormuz on Thursday, down from 17 a day earlier and below the 10-day average of 15.