Phase 3 trial shows 26% PFS improvement; call options volume jumps 2,599%

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AbbVie and Genmab’s Phase 3 EPCORE DLBCL-1 trial showed epcoritamab reduced risk of progression or death by 26% (HR 0.74; 95% CI 0.60–0.92) versus standard chemoimmunotherapy in 483 relapsed/refractory DLBCL patients. Concurrently, ABBV call option volume spiked 2,599%, signaling heavy bullish speculation ahead of regulatory discussions.

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