Codexis Achieves First Full-Length siRNA Synthesis with Stereochemistry Control and Cuts GWP by Over 50%
Codexis presented new data demonstrating full-length siRNA synthesis with precise phosphorothioate stereochemistry control via its ECO Synthesis platform at TIDES USA 2026. It also unveiled single-nucleotide initiation for enzymatic RNA synthesis and reported over 50% reduction in global warming potential plus 2.7-fold lower GWP on an input materials basis.
1. ECO Synthesis Stereochemistry Breakthrough
At TIDES USA 2026 Codexis revealed data showing its ECO Synthesis platform can synthesize full-length siRNA with precise phosphorothioate stereochemistry control, a first in RNA manufacturing. This stereochemical control enhances therapeutic potency and product consistency by ensuring the correct three-dimensional arrangement of nucleotides.
2. Single-Nucleotide Initiation Innovation
The company also introduced the capability to initiate enzymatic RNA synthesis directly from a single nucleotide, removing the need for chemically synthesized starter oligonucleotides. This advancement streamlines fragment ligation strategies and improves scalability and efficiency of siRNA production.
3. Sustainability and Environmental Efficiency
Codexis reported that its ECO Synthesis platform delivers over a 50% reduction in global warming potential compared to conventional synthetic approaches and achieves 2.7-fold lower GWP on an input materials basis. These environmental gains are driven by reduced organic solvent use, aqueous processing and the potential elimination of purification steps when using advanced enzymatic ligation.