Idorsia’s new Maturitas publication shows daridorexant 50 mg improves wake-after-sleep-onset by ~43 minutes, sleep latency by ~34 minutes and total sleep time by ~75 minutes with low somnolence. Health Canada has authorized JERAYGO at 12.5 mg (up to 25 mg) as first endothelin receptor antagonist for resistant hypertension in combination with three antihypertensive agents.