Tempus AI Reports 82.4% Stock Gain Driven by Genomics Growth and Positive EBITDA

TEMTEM

Over the past year, TEM shares climbed 82.4% on a Genomics revenue surge, scaling of its Data & Services segment, multiple FDA clearances and a shift to positive EBITDA. Positive EBITDA signals improved profitability and cash flow potential, supporting Tempus AI’s funding capacity for ongoing clinical and product development.

1. Robust Genomics Revenue Drives Year-Over-Year Gains

Tempus AI reported an 82.4% increase in its share price over the past twelve months, propelled by a 55% jump in Genomics service revenues. The company processed more than 100,000 sequencing tests in the most recent fiscal year, up from 65,000 tests a year earlier, translating into $180 million in top-line Genomics income. This segment now contributes over 60% of overall company revenues, underscoring growing adoption of Tempus’s precision oncology panels by major cancer centers and community hospitals.

2. Data & Services Segment Scales Rapidly

Revenue from Tempus’s Data & Services offerings expanded 70% year-over-year, reaching $75 million in the latest quarter. The company signed 12 new enterprise contracts with pharmaceutical partners for real-world evidence generation, lifting its active client count to 45. Strategic partnerships with three leading life-sciences firms have increased utilization of Tempus’s de-identified clinical database to support AI-driven drug discovery, driving recurring revenue and raising annual contract values by an average of 30%.

3. Regulatory Clearances and Path to Profitability

Tempus secured two additional FDA clearances for its tissue-based molecular companion diagnostics in the past six months, extending its portfolio to include assays for colorectal and gastric cancer biomarkers. These approvals enabled launch of in-house testing services at Tempus-owned laboratories, improving gross margins by 8 percentage points. In conjunction with stringent cost controls and automation of lab workflows, the company achieved positive adjusted EBITDA of $5 million in Q4, marking the first profitable quarter since its public listing.

4. High-Profile Research Presentations at ASCO GI

At the 2026 ASCO Gastrointestinal Cancers Symposium, Tempus will present eight abstracts detailing AI-driven biomarker discovery and predictive response models for GI malignancies. Highlights include a multi-center study demonstrating a 20% improvement in progression-free survival prediction over standard methods and a real-world analysis of 1,200 patients treated with immunotherapies. These presentations reinforce Tempus’s leadership in precision oncology analytics and are expected to generate new collaborations with academic institutions and biopharma sponsors.

Sources

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